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Best NMN Supplements 2024 | Biohacking your brain
6 November 2023 | James Kearslake
Table of Contents
What is NMN (Nicotinamide Mononucleotide)
As science and technology evolve at inconceivable speeds, so does the human desire for eternal life.
Or at least, eternal youth.
They say youth is wasted on the young, so are we fast approaching a world where our youth can be appreciated as we get old?
Nicotinamide Mononucleotide (NMN), is a compound gaining traction for its ability to slow down the ageing process at a cellular level, providing several benefits to cell protection and repair.
NMN is a naturally occurring compound found in every cell of the human body. A derivative of vitamin B3, also known as niacin, it serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme critical for various cellular processes. NAD+ is responsible for transferring electrons during metabolic reactions, making it a fundamental player in energy production, DNA repair, and cellular communication.
The Role of NMN in the Body
NMN’s primary role in the body is to boost NAD+ levels. This elevation of NAD+ plays a key role in various physiological functions:
- Energy Production – NAD+ is crucial for the proper functioning of mitochondria, the energy-producing powerhouses of cells. Elevating NAD+ levels can enhance cellular energy production, which may help combat age-related fatigue.
- DNA Repair – NAD+ is involved in DNA repair processes, maintaining genomic stability. Adequate NMN levels can contribute to better DNA repair mechanisms, reducing the risk of mutations and DNA damage.
- Sirtuin Activation – NAD+ is an essential co-factor for sirtuins, a group of proteins associated with longevity and cellular health. Sirtuins help regulate various biological processes, including metabolism and stress response. More below on understanding sirtuins
- Cellular Communication – Elevated NAD+ levels enhance cell-to-cell communication, contributing to overall cellular health and longevity.
Benefits of NMN Supplements
Research continues on NMN and its benefits, but current findings are showing exceptional results for improving cellular health and functioning.
Benefits of NMN include:
- Mitigates Against Age-Related Decline – Elevated NAD+ levels can help prevent age-related decline in mitochondrial function, with the potential to slow down the aging process and promote overall health and vitality. Read below on sirtuin activation to understand NMN’s longevity properties
- Enhances the Metabolism – NMN supplementation may support better metabolic function, improving insulin sensitivity and aiding weight management. Read below on sirtuin activation to understand increasing metabolic health
- Improves Cognitive Performance – Increased NAD+ levels supports brain health, improves cognitive function, and reduces the risk of age-related neurodegenerative diseases.
- Promotes Repair of DNA – Elevated NAD+ levels also aids in the DNA repair processes, reducing the risk of cancer and other age-related diseases. More below on NAD+ within the DNA repair process
- Improves Cardiovascular Health – NMN also improves blood vessel function, benefiting cardiovascular health, and reduces the risk of heart-related issues. More below on NMN improving cardiovascular health
- Increases Physical Endurance – NMN enhances physical performance and endurance by boosting energy production and reducing fatigue.
Understand Sirtuin Activation
Sirtuins are a group of proteins which play a role regulating several cellular processes, maintaining genomic stability, and supporting overall cellular health.
Sirtuins are closely linked to the concept of ‘sirtuin activation’, which involves enhancing the activity of these proteins. There are seven known sirtuin proteins in mammals, with SIRT1 being one of the most extensively studied and known commonly as ‘the longevity gene’.
Benefits of sirtuin activation:
- Longevity – Sirtuins have been determined for increasing lifespan in various organisms. When sirtuins are activated, they help repair damaged DNA, promote cellular survival, and maintain genomic stability, all of which contribute to a longer, healthier life.
- Cellular Repair – Sirtuins are involved in DNA repair mechanisms. By activating sirtuins, cells can more efficiently mend damaged DNA, reducing the risk of mutations and the development of diseases, including cancer.
- Metabolic Health – Sirtuins play a role in regulating metabolism. When activated, they enhance energy production and utilisation, improve insulin sensitivity, and contributing to better metabolic health.
- Stress Resistance – Sirtuins help cells respond to various stresses, including oxidative stress. By activating sirtuins, cells better cope with environmental and internal stressors, reducing cellular damage, and promoting resilience.
- Cognitive Health – Sirtuin activation has been linked to improved cognitive function and a reduced risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s.
- Cardiovascular Health – Sirtuins play a role in maintaining the health of blood vessels and the cardiovascular system, potentially reducing the risk of heart-related issues.
Sirtuin activation offers various key benefits to the body including increased longevity, enhanced DNA repair, improved metabolic health, stress resistance, and better overall cellular and cognitive health. These benefits are critical in the science and tech fight for development of anti-aging therapies and supplements.
Understand DNA Repair
DNA repair is a fundamental process within our cells that plays a critical role in maintaining genomic stability and preventing mutations. It is the intricate mechanism that identifies and corrects damage to the DNA molecule which serves as the genetic blueprint for all cellular processes.
DNA damage can occur from several causes, including environmental stressors, radiation, toxins, and normal metabolic processes.
When left unrepaired, DNA damage can lead to mutations and genomic instability, which over the long-term can cause significant disease including cancer, aging-related diseases, and genetic disorders.
Benefits of Optimal DNA Repair
Having an efficient DNA repair process benefits the body in myriad ways:
- Cancer Prevention – Proper DNA repair mechanisms help prevent the accumulation of mutations that can lead to uncontrolled cell growth and the development of cancer. It acts as a defence against the initiation and progression of cancer.
- Aging and Longevity – Effective DNA repair contributes to the maintenance of genomic stability, which slows down the aging process and promotes overall longevity. Reducing DNA damage and mutations is closely linked to a healthier and longer life.
- Cellular Function – When DNA repair is functioning optimally, cells can carry out their processes without interference from damaged DNA. This ensures that cells can perform their functions efficiently.
- Genetic Health – Effective DNA repair is essential for preventing and correcting genetic mutations that can be passed on to future generations. It helps maintain the genetic health of offspring.
- Disease Prevention – DNA repair is involved in protecting against various diseases, not only cancer but also neurological disorders, autoimmune conditions, and metabolic diseases. Keeping DNA damage in check supports overall health.
Autoimmune conditions are a broad group of diseases in which the immune system, which is designed to protect the body from harmful invaders like bacteria and viruses, mistakenly targets and attacks healthy cells and tissues within the body. This immune response against the body’s own tissues can lead to inflammation, tissue damage, and a wide range of symptoms. Some common autoimmune conditions include –
Common autoimmune conditions are:
- Rheumatoid Arthritis – This condition primarily affects the joints, leading to joint pain, swelling, and stiffness. It can also impact other organs and systems.
- Systemic Lupus Erythematosus – Lupus is a systemic autoimmune disease that can affect multiple organs, including the skin, joints, kidneys, and cardiovascular system.
- Multiple Sclerosis (MS) – MS is characterized by the immune system attacking the protective covering of nerve fibres, leading to communication problems between the brain and the rest of the body.
- Type 1 Diabetes – In this autoimmune condition, the immune system attacks and destroys the insulin-producing cells in the pancreas, leading to high blood sugar levels.
- Celiac Disease – This autoimmune disorder occurs when the immune system reacts to gluten, a protein found in wheat, rye, and barley, damaging the lining of the small intestine.
- Hashimoto’s Thyroiditis – This condition involves the immune system attacking the thyroid gland, leading to hypothyroidism and a range of symptoms.
- Graves’ Disease – This autoimmune disorder affects the thyroid gland as well but results in hyperthyroidism, causing symptoms like rapid heartbeat and weight loss.
- Inflammatory Bowel Disease (IBD) – Conditions like Crohn’s disease and ulcerative colitis involve chronic inflammation of the gastrointestinal tract.
- Psoriasis – An autoimmune disease that leads to the development of red, scaly patches on the skin.
- Vitiligo – In this condition, the immune system attacks and destroys the melanocytes, the cells responsible for skin pigmentation, leading to depigmented patches on the skin.
An optimised DNA repair process is crucial for safeguarding genomic integrity, preventing disease, and promoting a healthier, longer life.
These processes, influenced by factors like NAD+ levels and NMN, highlight the intricate and interconnected nature of various aspects of human health and well-being.
How NMN Improves Cardiovascular Health
NMN is also beneficial for taking to support our physical health and improving physical performance in cardio, resistance, and functional training.
It improves physical performance in several ways:
- Blood Vessel Function – NMN has the potential to enhance the function of blood vessels. This is crucial because healthy blood vessels support efficient blood flow and help regulate blood pressure. By promoting optimal endothelial function, NMN may reduce the risk of hypertension and related cardiovascular conditions.
- Anti-Inflammatory Effects – Chronic inflammation plays a significant role in the development of cardiovascular diseases. NMN, through its role in NAD+ production, can help regulate the body’s inflammatory response, potentially reducing inflammation in the cardiovascular system.
- Cellular Energy Production – A well-functioning cardiovascular system relies on the efficient production of energy by cardiac muscle cells. NMN supplementation may improve mitochondrial function within these cells, enhancing their ability to pump blood effectively.
- Protection Against Oxidative Stress – Oxidative stress can damage blood vessels and contribute to atherosclerosis, a condition where plaque accumulates in arteries. NMN’s role in DNA repair and reducing oxidative stress may help protect against these issues.
- Blood Lipid Profile – Studies suggest that NMN may have a positive impact on lipid metabolism, helping to maintain healthy cholesterol levels, which are vital for cardiovascular health.
Natural ways to Promote NMN Production
While NMN supplementation is the most effective for optimising daily production of NMN, you should also include natural ways to stimulate NMN production within the body:
- Dietary Sources – Foods rich in vitamin B3, such as poultry, fish, nuts, and green vegetables, can provide the necessary building blocks for NMN and NAD+ production. More on dietary recommendations below
- Intermittent Fasting – Fasting for extended periods can stimulate NAD+ production. It promotes the conversion of NMN into NAD+ in the body. More below on intermittent fasting and NAD+ production
- Exercise – Regular physical activity can increase NAD+ levels and improve NMN metabolism, supporting overall health.
- Sunlight Exposure – Exposure to natural sunlight may boost NAD+ production through a process involving vitamin D synthesis. More below on sunlight for NAD+ production
- Resveratrol – This natural compound found in red grapes and wine has been linked to sirtuin activation, potentially enhancing NMN’s benefits.
Dietary sources
Nicotinamide Mononucleotide (NMN) is a molecule that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme in various metabolic processes.
While there aren’t specific foods that directly contain NMN, you can consume foods that provide the building blocks and cofactors necessary for NAD+ synthesis.
Foods to promote NMN production in the body include:
- Tryptophan-Rich Foods – Tryptophan is an amino acid that serves as a precursor to NAD+. Foods high in tryptophan include turkey, chicken, dairy products, and soybeans.
- Niacin (Vitamin B3)-Rich Foods – Niacin is a key component in NAD+ synthesis. Foods rich in niacin include beef, poultry, fish, peanuts, and whole grains.
- Green Leafy Vegetables – Vegetables like spinach, kale, and broccoli provide nutrients like folate and B vitamins, which are essential for NAD+ production.
- Milk and Dairy Products – Dairy products like milk, cheese, and yogurt contain NADH, which can indirectly support NAD+ production.
- Mushrooms – Certain mushrooms, such as shiitake and maitake, contain compounds that may help in NAD+ synthesis.
- Fish – Fatty fish like salmon, tuna, and mackerel provide niacin and other nutrients that support NAD+ production.
- Poultry – Chicken and turkey are good sources of tryptophan, which can contribute to NAD+ synthesis.
- Legumes – Beans, lentils, and peas are rich in various nutrients, including tryptophan, niacin, and folate, all of which support NAD+ production.
- Nuts – Almonds and peanuts contain niacin and other nutrients that can indirectly promote NAD+ synthesis.
- Whole Grains – Whole grains such as brown rice, whole wheat, and oats provide niacin and other B vitamins essential for NAD+ production.
- Avocado – Avocado contains various B vitamins and folate that can support NAD+ synthesis.
- Red Meat – Beef and pork are rich in niacin and provide a source of precursors for NAD+.
Foods can provide essential nutrients for NAD+ synthesis, however the body’s ability to convert these nutrients into NAD+ is also influenced by various factors like genetics and overall health.
Intermittent Fasting and NAD+ Production
Intermittent fasting is an eating pattern that alternates between periods of fasting and eating. It has gained attention for its potential to stimulate NAD+ production, primarily through a process called NAD+ salvage pathway activation.
Intermittent fasting creates conditions that favor NAD+ production through the activation of the NAD+ salvage pathway and sirtuin activity.
During fasting, the body experiences a reduction in nutrient intake, including glucose. This nutrient deprivation triggers several responses that support NAD+ synthesis.
The increased availability of NAD+ in the body supports a wide range of cellular processes, potentially contributing to the health benefits associated with intermittent fasting, including improved metabolic health, longevity, and even the promotion of DNA repair.
The responses are that trigger NAD+ synthesis include:
- Activation of NAD+ Salvage Pathway – When glucose levels are low, the body prioritizes the conservation and recycling of NAD+. This involves the conversion of nicotinamide (a form of vitamin B3) into NAD+ through the salvage pathway. This process becomes more active during fasting.
- Increased Nicotinamide Phosphoribosyltransferase (NAMPT) Activity – NAMPT is an enzyme involved in the NAD+ salvage pathway. Fasting can lead to increased NAMPT activity, further promoting NAD+ synthesis.
- Sirtuin Activation – Intermittent fasting can also stimulate sirtuin activity. Sirtuins, as mentioned earlier, depend on NAD+ as a cofactor. With increased NAD+ levels during fasting, sirtuins can become more active, contributing to various cellular and metabolic benefits.
.. However, it’s important to approach fasting with caution and consider individual health conditions and nutritional needs, as it may not be suitable for everyone. Consulting a healthcare professional before starting any fasting regimen is advisable.
Sunlight Exposure and NAD+ Production
Exposure to natural sunlight is another factor that can increase NAD+ production, primarily through a process involving vitamin D synthesis.
- Vitamin D Synthesis – Sunlight exposure on the skin triggers the conversion of a precursor molecule, 7-dehydrocholesterol, into vitamin D. This conversion occurs primarily in the epidermis, the outermost layer of the skin. Vitamin D is biologically inactive and requires further processing in the liver and kidneys to become the active form, calcitriol.
- Vitamin D and NAD+ Connection – Vitamin D receptors (VDRs) are present in various tissues and cells throughout the body. When vitamin D is activated, it can influence various cellular processes, including NAD+ production.
- Cellular Benefits – Vitamin D, through its influence on NAD+, can support cellular health and energy metabolism. Increased NAD+ levels can enhance mitochondrial function and cellular energy production, which is crucial for overall health and vitality.
- DNA Repair – Adequate vitamin D levels, potentially influenced by sunlight exposure, can contribute to better DNA repair mechanisms. This, in turn, reduces the risk of mutations and DNA damage.
Sunlight exposure, when it leads to the synthesis of vitamin D, therefore indirectly influences NAD+ levels.
If your location and lifestyle do not allow for regular exposure to the sun, you should be taking daily vitamin D supplements for the critical bodily processes that vitamin D supports. The supplement will therefore also contribute to NAD+ production.
Potential Risks of NMN Supplements
It’s important to note that while NMN supplementation shows promise, there are potential risks and uncertainties:
- Lack of Long-Term Data – The long-term effects of NMN supplementation are not yet well-understood, as it is a relatively recent area of research.
- Dosing Uncertainty – Determining the ideal dosage of NMN for different individuals remains a challenge, and excessive doses may have adverse effects.
- Quality and Purity – The quality and purity of NMN supplements can vary significantly between manufacturers, potentially affecting their efficacy and safety.
- Interactions – NMN may interact with certain medications or medical conditions. It’s crucial to consult a healthcare professional before taking NMN supplements.
- Cost – High-quality NMN supplements can be expensive, and the cost may be a barrier for some individuals.
The Best NMN Supplements UK
A leading product on the market, Charava has established itself as a highly reputable brand in the nootropics field, where quality is worth paying for.
Buy Now | £64.99 | Charava
Benefits of NAD+ :
- Anti-Aging Boosted NAD+ levels, promote healthy aging by repairing damaged DNA.
- Increase Energy Increased NAD may increase cell vitality, relieve fatigue, and make your day full of energy.
- Support Cognitive Function NAD may helps to enhance brain function, promote metabolism, and get better sleep.
- Sirtuin Activating Compound will encourage SIRTUINS, the body’s longevity-genes to promote healthy aging to make sure you look good and feel good.
250mg | High strength capsule; it is the ultimate NAD+ boosting anti-ageing supplement and is entirely natural. It will boost your energy, while providing countless health enhancing benefits.
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Buy Now | £42.99 | Youth & Earth
Tested to ensure it’s endotoxin-free.
Increased NAD+ levels stimulate energy metabolism, DNA repair and SIRTUIN activity (SIRTUINS are the longevity genes shown to be active during caloric restriction and life extension in many animal models).
- Minimum 99% pharmaceutical grade
- Tested for heavy metals, toxins and endotoxins
- Manufactured in a GMP facility to USA-grade standards
- Stable in the most extreme heat conditions
- Suitable for vegans & vegetarians
- Gluten, GMO & Soy Free
Boost your vitality with NMN, a potent NAD+ precursor with anti-aging benefits.
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Their high-quality supplement enhances cellular energy, optimises metabolism, and supports cognitive function, fostering a conducive environment for overall health and longevity.
Experience:
- boosted energy levels
- improved sleep quality
- sharpened mental focus
- enhanced metabolism.
Enteric liposomal capsules, nicotinamide mononucleotide, NAD+ booster
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UltraHealth has made the only Enteric Liposomal Capsules, Nicotinamide Mononucleotide, NAD+ Booster.
Other than our NAD+ boosters, which uses our prohibitive Liposomal Cases, NR or nicotinamide riboside is found to work amazingly better at making more NAD+! Both UltraHealth NAD+ allies and NR things are the most raised flawlessness in the business. All of our things show our continuous untouchable tests and advancing unfaltering quality audit.
250mg | Liposomal NAD+ boosting compound
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Lower your cost per capsule with this 300 count, 300 day supply pouch. An empty, labeled bottle is included for your convenience.
Both of our NAD+ Boosters use our proprietary Liposomal Capsules, NR or nicotinamide riboside is also an excellent choice for creating more NAD+! Both UltraHealth NAD+ boosters, NMN and NR, are the highest purity in the industry. All our products show our current third party tests and ongoing stability studies.
With added astaxanthin, Feel Supreme say their tablets are more efficient than other NMN supplements.
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- NAD+ information – Of several forms of vitamins B3, NR has been shown to be the most effective supplement at raising NAD+ levels. The results being to positively support the natural aging process, tiredness and fatigue.
- Healthy aging – NAD+ production has been shown to drop as we age. Raising NAD+ levels may support vision loss and a healthy heart and regulate metabolism
- Why add astaxanthin? – also known as ‘the king of carotenoids’, it’s 550 times more effective as an antioxidant than vitamin E, nearly 6,000 times stronger than Vitamin C, and 550 times richer as a source of antioxidants than green tea or other Catechins.
- Tiredness and fatigue – NR may help to support the reduction in tiredness and fatigue, regulate metabolism and support a healthy heart. NR and Astaxanthin combined, may also help fight harmful inflammation,
Aids mental performance and regulates metabolic system.
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- Provides coenzyme NAD – Our potent NAD tablets contain 37.5mg of high strength b-Nicotinamide Adenine Dinucleotide.
- Improvements in mental performance and boosts energy – NAD can be used to improve cognitive performance, mental improvement, supports metabolism and increases energy. Furthermore, NAD can be used to reduce oxidative stress.
- Formulated by chemists and therapists – NAD Plus has been formulated for Eudeamon by Specialist Chemists and Therapists. This dietary supplement has been designed to be used alongside a healthy balanced diet to enhance general well-being and mental health.
NADH+ 50mg combined with CoQ10 200mg to elevate natural energy levels and improve cognitive performance.
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- What is NADH – NADH, a coenzyme derived from vitamin B-3 and naturally produced in the body, is essential for fundamental metabolic processes, respiration, the breakdown of sugars and fats, and the production of ATP, which serves as the primary energy molecule in our cells.
- Max strength – Coutihot provides premium, honest supplements to support your journey to a healthier lifestyle. Each capsule of Coutihot NADH contains 50mg NADH, 200mg CoQ10, 150mg D-Ribose, and 100mg Grape Seed Extract.
- Repair your body – NADH is found in the cells of every living organism; it is often referred to as the ‘powerhouse of the cell.’ This carefully crafted formula is designed for demanding and active lifestyles. It enhances your basic metabolism, optimises cognitive performance, and supports cellular health and longevity. NADH is essential for the production of ATP (cellular energy) and takes it to a new level.
- Energy booster – as we age, our energy levels naturally decline. NADH can help improve your daily energy levels. It supplies energy to the brain, nerves, muscles, heart, and all other organs to help them function optimally.
Who is James Kearslake?
Having been biohacking my mind and body long before it became fashionable, I’ve always lived by the benefits of nature’s resources to improve cognitive and physiological performance. Using my years of experience, products, and wellness practices, I’m now helping others elevate their cognitive performance to help build the life they want. I save you the time I’ve spent learning, so you can focus your time on building.
Proudly AI Supported
I proudly use AI to support development of my articles. As a heavily dyslexic person, writing can be a time consuming process with words often jumbled up and sentences the wrong way round. AI has become my crutch; allowing me to share the immense interest in my mind, while making content creation quicker and more accurate. AI is my benefit.
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