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the 'longevity molecule'
extending lifespans

Fesitin | Biohacking your body
8 November 2023 | James Kearslake
Table of Contents
Fun Fact

Fisetin, often referred to as the ‘Longevity Molecule’, is a fascinating compound that has gained attention in the field of anti-aging research. Some studies have suggested that fisetin may have the potential to extend lifespan and promote healthier aging, making it a subject of interest for those seeking to unlock the secrets of a longer, healthier life.

What Is Fisetin

Our brains are highly susceptible to oxidative stress and inflammation, which leads to cognitive decline over time. Fisetin has been on the market for a number of years, taken for its ability to protect and improve brain health.

As a potent antioxidant, it scavenges harmful free radicals, reducing the damaging effects of oxidative stress in the brain.

It also improves the health of our neural network, maintaining a healthy nervous system, and enhances synaptic function and communication between neurons, resulting in improved cognitive abilities including learning and memory.

Fisetin, scientifically known as 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one, is a natural bioactive compound classified as a flavonoid, and found in various fruits and vegetables.

A scan of the human brain and neural network showing a healthy, balanced, and calm mind with improved cognitive functioning_Benefits of taking

Benefits of Fisetin Supplements

Fisetin supplements have become very popular in recent years in the biohacking community and wellness industry.

Benefits of taking fisetin supplements include:

  1. Improved Brain Health – Fisetin offers several benefits to supporting brain health, including powerful neuroprotective properties, improved synaptic connectivity, and the ability to improve learning and memory. More on this below.
  2. Neuroprotective Benefits – Its neuroprotective properties protect the neurons throughout our central nervous system. This directly supports healthy regulation of a central nervous system and can reduce the chances of neurodegenerative conditions like Alzheimer’s disease.
  3. Enhanced Antioxidant Protection – Fisetin is a potent antioxidant which helps combat oxidative stress. Oxidative stress is associated with chronic diseases, aging, and cellular damage. It scavenges harmful free radicals, reducing the risk of oxidative damage and the long-term health risks like cancer.
  4. Anti-Inflammatory Effects – Its anti-inflammatory properties help alleviate chronic inflammation, being a common root cause of many health issues, including heart disease, arthritis, and certain types of cancer.
  5. Joint Health – Its anti-inflammatory properties also support joint health, reducing inflammation, making it appealing to individuals with arthritis or other inflammatory conditions.
  6. Metabolic Health – It also assists with regulating blood sugar levels and improving insulin sensitivity, aiding physical performance for those training regularly and supporting weight management objectives. More on this below.
  7. Aging and Longevity – New research is indicating fisetin may have the potential to extend lifespan and promote healthy aging. However, research needs to be conducted on humans to understand how these benefits transfer to the human body.
an image of the male anatomy in green with a large heart on the outside to show a large and healthy cardiovascular system from Quercetin_Benefits of taking

Fisetin Improves Cognitive Function

Fisetin offers several ways in which is supports brain health, improving the physiology of the brain, as well as cognitive function.

Cognitive function encompasses various mental processes, including memory, attention, problem-solving, and creativity. Therefore, Fisetin is taken widely in the biohacking community as a nootropic to aid cognitive performance.

Fisetin improves brain function in several ways:

  1. Antioxidant Protection – Oxidative stress occurs when free radicals, unstable molecules, damage brain cells and their components. Fisetin, a potent antioxidant, neutralises these free radicals, reducing the risk of damage. This defence mechanism is crucial for preventing the gradual decline in cognitive function associated with aging.
  2. Anti-Inflammatory Effects – Chronic inflammation in the brain is linked to neurodegenerative conditions like Alzheimer’s and Parkinson’s disease. Fisetin’s anti-inflammatory properties help in quelling this inflammation, reducing the risk of cognitive decline. By decreasing inflammatory markers, fisetin supports the brain’s overall health.
  3. Neuroprotection – Fisetin goes a step further by promoting the survival and health of neurons, the building blocks of our nervous system. This property is particularly important for maintaining cognitive function and memory. Studies suggest that fisetin may help protect neurons from damage and degeneration, which can be a key factor in conditions like Alzheimer’s disease.
  4. Synaptic Plasticity – Fisetin also influences synaptic plasticity, a vital component of learning and memory. It helps enhance synaptic function and communication between neurons, which can result in improved cognitive abilities.
  5. Aging and Longevity – Some research has suggested that fisetin may play a role in extending lifespan and promoting healthier aging. While more studies are needed to fully understand this aspect, it adds to the intrigue of fisetin’s potential impact on brain health and longevity.
  6. Memory Enhancement – Fisetin’s neuroprotective properties are believed to support memory retention and recall. This makes it a potential ally in combating age-related memory loss.
  7. Mood and Mental Clarity – Some users of fisetin supplements have reported improved mood and mental clarity. While individual responses may vary, these anecdotal accounts are encouraging.
  8. Learning and Adaptation – Fisetin’s impact on synaptic plasticity can help individuals learn more effectively and adapt to new challenges.

Blood Sugar Regulation

Perfect for those looking to manage their blood sugar response, insulin sensitivity, or use supplements to support a weight management objective, fisetin is an ideal supplement.

Fisetin supports blood sugar and weight management in several ways:

  1. Improved Insulin Sensitivity – Fisetin has been studied for its role in enhancing insulin sensitivity. Insulin is a hormone that helps regulate blood sugar levels. Reduced insulin sensitivity, known as insulin resistance, is a key factor in type 2 diabetes. Fisetin has been shown to enhance insulin signaling pathways, allowing cells to better respond to insulin. A study published in the “Journal of Cellular Physiology” in 2019 found that fisetin improved insulin sensitivity in skeletal muscle cells. This enhanced sensitivity helps glucose enter cells more efficiently, lowering blood sugar levels.
  2. Reduced Glucose Production – The liver plays a crucial role in maintaining blood sugar levels. It can produce excess glucose, contributing to high blood sugar in individuals with diabetes. Fisetin has demonstrated the ability to reduce glucose production in the liver, further aiding in blood sugar control. A study in “Molecular and Cellular Endocrinology” in 2013 showed that fisetin reduced glucose production in liver cells.
  3. Protection Against Beta-Cell Damage – Beta cells in the pancreas produce insulin. In type 2 diabetes, these cells can become damaged, reducing insulin production. Fisetin’s antioxidant properties may help protect beta cells from oxidative stress, preserving their function. A study in “Cell Biochemistry and Biophysics” in 2015 revealed fisetin’s potential in safeguarding beta cells.
  4. Anti-Inflammatory Effects – Chronic inflammation is linked to insulin resistance and diabetes. Fisetin’s anti-inflammatory properties can help mitigate this issue. By reducing inflammation, fisetin supports overall metabolic health.
  5. Potential in Diabetes Management – While more research is needed, studies have suggested that fisetin may be a valuable adjunct to traditional diabetes management strategies. It has the potential to enhance the effectiveness of insulin therapy and other diabetes medications.

Fisetin in Cancer Prevention and Treatment

Several studies have suggested that fisetin may be beneficial for use during courses of cancer treatment:

  1. Antioxidant Defence – Fisetin’s robust antioxidant properties are crucial in preventing cancer. It neutralizes free radicals, which are known to damage DNA and lead to mutations that can initiate cancer. A study published in the journal “Molecular Medicine Reports” in 2015 found that fisetin reduced oxidative stress and DNA damage, highlighting its potential in cancer prevention.
  2. Anti-Inflammatory Action – Chronic inflammation is a key driver of cancer development. Fisetin’s ability to suppress inflammation may inhibit the progression of cancer. A study in the journal “Cancer Research” in 2014 demonstrated fisetin’s effectiveness in reducing inflammation in colon cancer cells.
  3. Apoptosis Induction – Fisetin has shown promise in promoting apoptosis, which is the programmed cell death of damaged or cancerous cells. Research published in “Biochemical Pharmacology” in 2008 revealed that fisetin induces apoptosis in prostate cancer cells, potentially preventing their uncontrolled growth.
  4. Inhibition of Tumour Growth – In a study published in the journal “Cancer Letters” in 2012, fisetin was found to inhibit the growth of lung cancer cells. This inhibition was attributed to fisetin’s impact on cell cycle arrest and the regulation of proteins involved in cancer development.
  5. Metastasis Suppression – Fisetin has demonstrated the ability to inhibit the spread of cancer cells to other parts of the body, a process known as metastasis. In a study published in PLOS ONE in 2014, fisetin was shown to reduce the migration and invasion of breast cancer cells.

It’s important to note that while these studies show promise, more extensive clinical trials are necessary to confirm the efficacy of fisetin in preventing or treating cancer in humans. Individual responses may also vary between people, meaning fisetin should not be considered as a standalone treatment for cancer. It is essential to consult with a healthcare professional when considering any form of cancer prevention or treatment outside of the prescribed treatment from medical professionals.

Natural Ways to Promote Fisetin in the Body

Supplements will always remain the most effective way to getting a consistent dose of a product into your system. However, we always recommend including natural sources of a compound into your diet so you can get the added benefit of combined micronutrients and vitamins.

Foods offering a natural source of fisetin include:

  1. Strawberries – Strawberries are among the richest sources of fisetin. Enjoy a bowl of fresh strawberries or add them to your morning smoothie.
  2. Apples – An apple a day not only keeps the doctor away but also provides a natural dose of fisetin.
  3. Onions – Cook with onions to add flavour to your dishes while reaping the benefits of fisetin.
  4. Cucumbers – Include cucumbers in salads or enjoy them as a refreshing snack.
  5. Kale – This leafy green vegetable contains fisetin and is an excellent addition to your diet for overall health.

Potential Risks of Fisetin Supplements

Fisetin is generally considered safe, however there are potential risks to be observed before taking the supplement:

  1. Drug Interactions – Fisetin may interact with certain medications, particularly blood thinners. It’s essential to consult with a healthcare professional before adding fisetin supplements to your regimen, especially if you are taking prescription drugs.
  2. Dosage – Ensure you follow the recommended dosage guidelines for fisetin supplements. Excessive intake may lead to adverse effects, such as gastrointestinal discomfort.
  3. Allergic Reactions – Some individuals may be sensitive or allergic to fisetin or other components of the supplement. If you experience any adverse reactions, discontinue use and consult a healthcare provider.
  4. Pregnancy and Breastfeeding – The safety of fisetin supplements during pregnancy and breastfeeding has not been established. Consult a healthcare professional before using fisetin if you are pregnant or nursing.

The Best Fisetin Supplements UK

A powerful antioxidant that maintains glutathione levels and mitochondrial function. It crosses the blood brain barrier, protecting neuronal function.

Buy Now | £24.99 | Charava

Fisetin is a bioflavonoid antioxidant which can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. It has potential to cross the blood brain barrier, which may help maintain neuronal function.

Other than strawberries, fisetin is scarce in fruits and vegetables compared to other flavonoids, making supplementation important.

One of the main hallmarks of ageing is increased cellular senescence.

Liposomal Fisetin and Quercetin is our senolytic supplement capable of selectively destroying senescent cells in old tissues.

Buy Now | £39.99 | Youth & Earth


Senescent cells, also known as Zombie cells, accumulate with age. This may result in higher levels of specific senescence-associated proteins, which drive ageing-related processes and promote ageing-related disease.

  • Potent Natural Senolytic Compound of Fisetin & Quercetin
  • Selectively removes Zombie Cells
  • Anti Inflammatory and may improve Physical Function
  • Gluten, GMO & Soy Free
  • Suitable for Vegans and Vegetarians

98% Purity Natural Fisetin Supplement

Buy Now | £28.45 | Vitality Pro

Fisetin 100mg x 60 Capsules | Third Party Tested Over 98% Purity

Natural Fisetin Supplement

A highly effective, complex blend manufactured by Life Extension.

Buy Now | £39.89 | Life Extension

  • HIGH-DOSAGE: One dose, one tablet, Fisetin by Life Extension contains various plant extracts that you can feed your body daily
  • HIGH BIO-AVAILABILITY: Life Extension’s Fisetin is characterised by good bioavailability and is suitable for a vegan lifestyle.
  • HIGH QUALITY: Life Extension’s isoflavone capsules are tested in independent laboratories for quality and purity.
  • WITHOUT UNWANTED ADDITIVES: Life Extension capsuled are gluten-free and produced without genetic engineering.

Liposomal Encapsuled for Increased Nutrient Utilisation | Powerful Anti Aging and Rejuvenating Properties

Buy Now | £18.99 | Cestfilo

Fisetin and quercetin are flavonols, a type of flavonoid that occurs naturally in plants. Due to their strong antioxidant properties, flavonols have been associated with a number of health benefits. These two active ingredients have been shown to help support brain health, memory and cognition. Learn more about this premium brain-supporting blend today!

Fisetin and quercetin both play an important role in healthy ageing. Unlike other fisetin supplements, we have adopted the latest liposome encapsulation technology with liquid softgel form developed to enhance the absorption of fisetin and facilitate quick access to nutrients so you get the best results. Try our fisetin & quercetin supplements and be at the forefront of cutting edge research!

Final Thoughts

Becoming known as the ‘Longevity Molecule’, fisetin is an interesting supplement which I think we’ll see more of in the anti-aging space in the coming years.

Its many benefits for brain health and cognitive function already positions it high in the nootropics chart with the biohacking community and wellness experts, so any supplementary benefits like lifespan longevity could see its popularity explode.

It is certainly a product the high performers should be taking for its ability to improve cognitive function, learning, and memory.

Until it is confirmed to be an elixir of eternal youth, we will continue taking fisetin for its benefits to brain health, and hope that in the process, we’re extending our lifespan beyond current years, and will live until the ripe old age of 110.

Who is James Kearslake?

Having been biohacking my mind and body long before it became fashionable, I’ve always lived by the benefits of nature’s resources to improve cognitive and physiological performance. Using my years of experience, products, and wellness practices, I’m now helping others elevate their cognitive performance to help build the life they want. I save you the time I’ve spent learning, so you can focus your time on building.

Proudly AI Supported

I proudly use AI to support development of my articles. As a heavily dyslexic person, writing can be a time consuming process with words often jumbled up and sentences the wrong way round. AI has become my crutch; allowing me to share the immense interest in my mind, while making content creation quicker and more accurate. AI is my benefit.

Buy Now | £39.89


Buy Now | £39.99

Buy Now | £24.99

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